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Title:: The Effect of Relative Position between Electrode Lead Wire and TMS Coil on TMS-EEG Artifacts

Author(s):: JIN Fang; JIN Jingna; LIU Zhipeng; YIN Tao; Institute of Biomedical Engineering ,Chinese Academy of Medical Science &Peking Union Medical College,Tianjin 300192,China

Keywords:: Transcranial magnetic stimulation; Electroencephalography; Artifact ; Electric field; Electrode lead wire

摘要:: 通过分析经颅磁刺激线圈放电时的电场分布，探索磁刺激输出脉冲对脑电采集帽产生的伪迹信号来源。我们通过建立八字线圈感应电场分布的半无界空间数学模型，获得八字线圈感应电场的分布特性，分析磁刺激影响脑电采集回路的两种影响因素，我们用matlab软件仿真刺激线圈与脑电极线成不同角度、不同距离时产生的伪迹信号的变化趋势，通过模型试验和人体实验验证这种趋势的准确性；结果显示，脑电导线重合于线圈长轴，产生脑电伪迹最小，当线圈转动其他角度或当线圈下移时伪迹会逐渐增大，最大伪迹幅值是最小伪迹幅值的约10倍。在TMS-EEG试验中，伪迹信号的幅值、持续时间与线圈摆放位置、角度有关。通过实验前合理排布脑电极线可降低伪迹信号幅值、持续时间等参数，提高磁刺激下脑电信号特征信号提取的准确性。

Abstract:: To find the sources of the artifacts from the combination with transcranial magnetic stimulation and electroencephalography(TMS-EEG) through the study of electric field of TMS coil. We established a mathematical model in semi infinite space, analysed the electric field of TMS coil, and tested the angle and distance effects from models to subjects study. The artifacts would be minimum if electrode lead wire coincide with major axis of TMS coil, and amplitude would be increased roughly 10 times，if the angle of the electrode lead wire was changed. The artifacts correlated with angle and distance from coil to electrode lead wire. Our research makes it possible to reduce artifacts by rearrangement of electrode lead wire.