文章摘要

文章信息/Info

Title:: The Migation of Irganox 1010 in the Sterile Hypodermic Syringes for Single Use

作者:: 李永贵1; 2; 张锡霞1; 2; 王晶1; 2△; 王勤2; 3; 1.山东省药学科学院，山东省化学药物重点实验室山东济南 250101；2.山东福瑞达医药集团公司，山东省黏膜与皮肤给药技术重点实验室山东济南 250101；3.山东省药学科学院，山东省医用高分子材料重点实验室山东济南 250101

Author(s):: LI Yonggui1; 2; ZHANG Xixia1; 2; WANG Jing1; 2; WANG Qin2; 3; 1.Shandong Academy of Pharmaceutical Sciences，Shandong Provincial Key Laboratory of Chemical Drug，Jinan 250101，China；2.Shandong Freda Pharmaceutical Group Company, Shandong Provincial Key Laboratory of Mucosal and Transdermal Drug Delivery Technology，Jinan 250101；3.Shandong Academy of Pharmaceutical Science，Shandong Provincial Key Laboratory of Biomedical Polymers，Jinan 250101

Keywords:: Sterile hypodermic syringe; Irganox 1010; High performance liquid chromatography; Migration; Safety evaluation

摘要:: 本研究建立了测定抗氧剂1010的HPLC方法，并对一次性使用无菌注射器中抗氧剂1010在去离子水、0.1 M盐酸溶液、0.1 M氢氧化钠溶液、无水乙醇、丙二醇及乙腈中的迁移溶液进行了测定，为一次性使用无菌注射器的安全使用提供实验依据。

Abstract:: To establish the HPLC method of determining irganox 1010，the migration solution of irganox 1010 is tested in the water, 0.1 M hydrochloric acid, 0.1 M sodium hydroxide, ethanol, propylene glycol and acetonitrile and to provide experiment basis for single use of sterile hypodermic syringes.