文章摘要

文章信息/Info

Author(s):: YANG Xiaobin; ZHOU Miao; Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology ?Hospital of Guangzhou Medical University, Guangzhou 510140, China

Keywords:: Vascularization; Jaw; Bone tissue engineering; Scaffold; Seed cell; Growth factor; Surgical method

摘要:: 组织工程是颌骨缺损修复的研究热点和重要方向，但其血管化问题尚未得到完全解决，这限制了其临床应用于大体积颌骨缺损的修复。支架、种子细胞和生长因子作为组织工程三要素在血管化进程中扮演重要角色。因此，各种体内外促血管化策略如应用促血管生成细胞、复合促血管生长因子、优化支架的成分与外形及内部结构设计、采用外科手段等近来得到广泛研究，本文将对此作一综述。

Abstract:: With the development of tissue engineering technology, repairing jaw defects using tissue-engineered bone has become a hot topic. However, vascularization still remains an unsolved problem of this field, especially for repairing large volume jaw defects in clinical application. As the three essential elements of tissue engineering, Scaffold, cells and growth factors, play key roles in the vascularization of tissue-engineered constructs. Consequently, various in vitro and in vivo vascularization-promoting methods, such as optimization of scaffold composition and structure, loading of angiogenic cells and angiogenic factors, as well as the use of various surgical methods were recently extensively investigated. Therefore, the present paper aims to make a summary.