|本期目录/Table of Contents|

[1]彭丽娜△,赵艳薇,彭丽研.L-肉碱对NAFLD脂肪肝大鼠肝脏线粒体能量代谢及抗氧化能力的影响[J].生物医学工程研究,2017,03:258-261.
　PENG Lina,ZHAO Yanwei,PENG Liyan.Effect of Liver Mitochondrial Energy Metabolism and Antioxidant Capacity with L-carnitine on Fatty Liver in Rats[J].Journal of Biomedical Engineering Research,2017,03:258-261.
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L-肉碱对NAFLD脂肪肝大鼠肝脏线粒体能量代谢及抗氧化能力的影响(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2017年03期
页码:
258-261
栏目:
出版日期:
2017-09-25

文章信息/Info

Title:
Effect of Liver Mitochondrial Energy Metabolism and Antioxidant Capacity with L-carnitine on Fatty Liver in Rats
文章编号:
1672-6278 (2017)03-0258-04
作者:
彭丽娜1△; 赵艳薇2; 彭丽研3
1.廊坊师范学院运动人体科学教研室，河北 廊坊 065000；2.廊坊师范学院健美操教研室，河北 廊坊〓065000；3.北京北大方正软件技术学院，河北 廊坊 065000
Author(s):
PENG Lina1; ZHAO Yanwei2; PENG Liyan3
1.Department of Human Movement Science, Langfang Teachers University，Langfang 065000，Hebei，China；2.Aerobics Teaching and Research Section of Langfang Teachers University，Langfang 065000，Hebei；3.College of Physical Education , peking university founder technology college，Langfang 065000，Hebei
关键词:
L-肉碱; 脂肪肝; 大鼠; 肝脏线粒体; 能量代谢; 抗氧化
Keywords:
L-carnitine;  Fatty liver;  Rat;  Liver mitochondria;  Energy metabolism;  Antioxidant
分类号:
G804.7；R318
DOI:
10.19529/j.cnki.1672-6278.2017.03.14
文献标识码:
A
摘要:
研究L-肉碱对NAFLD脂肪肝大鼠肝脏线粒体能量代谢及抗氧化能力的影响。脂肪肝大鼠48只，随机分为对照组、肉碱组、运训组和肉碱+运训组。运训组和肉碱+运训组进行6周运动，肉碱组和肉碱+运训组每日灌胃一次肉碱（500 mg/kg）。6周后各组大鼠进行力竭运动，即刻麻醉取出肝脏提取线粒体，测定线粒体呼吸链酶RCCI～IV活性及自由基代谢相关指标。与对照组比，肉碱组大鼠肝脏线粒体呼吸链RCCII，运训组RCCI、RCCIII，肉碱+运训组RCCI、RCCII、RCCIII活性均显著提高。与肉碱组比，肉碱+运训组RCCI、RCCIII活性显著提高。与运训组比，肉碱+运训组RCCI活性显著提高。与对照组比，肉碱组、肉碱+运训组大鼠肝脏线粒体GSH-Px活性显著提高；与对照组比，三组SOD 活性显著提高，MDA含量降低。与肉碱组比，肉碱+运训组SOD活性显著提高；与运训组比，肉碱+运训组GSH-Px活性显著提高。补充L-肉碱、运动、L-肉碱+运动均可提高非酒精性脂肪肝大鼠肝脏线粒呼吸链酶活性，提高线粒体能量代谢速率及抗氧化损伤能力，补充L-肉碱结合运动训练组效果更加显著。
Abstract:
To study the effects of L-carnitine on mitochondrial energy metabolism and antioxidative capacity in liver of NAFLD fatty liver. 48 rats were randomly divided into control group, carnitine group, exercise group and L-carnitine+exercise group. Carnitine group and L-carnitine+exercise group were exercised for 6 weeks, carnitine and L-carnitine+exercise group were cared a carnitine once a day(500 mg/kg). After 6 weeks, the rats in each group were subjected to exhaustive exercise. The mitochondria were extracted from the liver immediately after anesthesia, and the activities of mitochondrial respiratory chain enzyme RCCI~IV and free radical metabolism were measured.Compared with control group, the RCCII of carnitine rat liver mitochondrial respiratory chain,the RCCI of sports training group, RCCIII, L-carnitine+exercise group RCCI, RCCII, RCCIII activity were significantly increased. Compared with carnitine group, L-carnitine+exercise group RCCI, RCCIII activity significantly increased. Compared with sport group, L-carnitine+exercise group RCCI activity significantly increased. Compared with control group, carnitine group, L-carnitine+exercise groups’ rat liver mitochondrial GSH-Px activity was significantly improved; compared with the control group, SOD activity, MDA levels of three groups were significantly increased. Compared with carnitine group, L-carnitine+exercise group significantly increased the activity of SOD; Compared with sport group, the GSH-Px activity significantly of L-carnitine+exercise group increased. L-carnitine supplement, sports, L-carnitine+exercise can improve the reap respiratory chain activity of nonalcoholic fatty liver in rats , increase mitochondrial energy metabolism rate and antioxidant capacity, supplement L-carnitine combined with exercise training group is more significant.

参考文献/References

备注/Memo

备注/Memo:
(收稿日期：2017-01-20) △通信作者Email:penglina215@126.com
更新日期/Last Update: 2017-09-25