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Title:: The Preparation and Properties of Semi-interpenetrating Networks Starch Hemostatic Dressings

作者:: 郈秀菊1; 朱爱臣1; 王军2; 孙淑娜2; 王晓晨1; 王传栋1△; 1.山东省药学科学院，山东省医用高分子材料重点实验室，济南250101；2.山东省中医院，济南250011

Author(s):: HOU Xiuju1; ZHU Aichen1; WANG Jun2; SUN Shuna2 ; WANG Xiaochen1 ; WANG Chuandong1; 1. Shandong Academy of Pharmaceutical Sciences, Shandong Provincial Key Laboratory of Biomedical Polymers, Jinan 250101，China；2. Shandong Provincial Hospital of Traditional Chinese Medical, Jinan 250011

Keywords:: Starch; Hydroxyethyl cellulose; Hemostatic dressings; Semi-interpenetrating networks; Biodegradation

摘要:: 本研究采用低温等离子体技术和冷冻干燥工艺制备了半互穿网络淀粉基止血海绵。通过测试止血海绵的吸水率和膨胀率优化了实验方案及制备工艺，扫面电镜照片显示，本研究制备的海绵具有均匀相互贯通的网络骨架多孔结构。兔肝肾止血实验表明该止血海绵止血快，出血量少，具有良好的止血效果。大鼠体内降解实验表明，淀粉止血海绵4周后可被降解吸收。本研究制备的半互穿网络淀粉基止血海绵，是一种快速有效的可吸收的止血敷料，在外科手术中具有很好的应用前景。

Abstract:: In this paper, the low temperature plasma technology and freeze drying technology was used to get the semi-interpenetrating networks starch hemostatic dressings. The experiment design scheme and preparation technology of the starch hemostatic dressings were optimized by the test results of the water absorption and expansion rate. The scanning electron microscopy images showed that the sponges prepared by this experiment had a uniform porous structure of the network skeleton. Rabbit liver and kidney bleeding experiments showed that the bleeding time was shorter and the blood loss was fewer by using the starch hemostatic dressings, and it was showed that the starch hemostatic dressings had good hemostatic effect. The results of the degradation in mice showed that the starch hemostatic dressings had been absorbed after four weeks. The semi-interpenetrating networks starch hemostatic dressing was a kind of rapid and effective absorbable hemostatic dressing. It has the very good application in the surgery.