|本期目录/Table of Contents|

[1]李育强,智倩倩△,杨茂丽,等.超滑抗菌硅胶导尿管的制备与性能研究[J].生物医学工程研究,2018,01:101-106.
 LI Yuqiang,ZHI Qianqian,YANG Maoli,et al.The preparation and property research of ultra smooth antimicrobial silicone rubber catheters[J].Journal of Biomedical Engineering Research,2018,01:101-106.
点击复制

超滑抗菌硅胶导尿管的制备与性能研究(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年01期
页码:
101-106
栏目:
出版日期:
2018-03-25

文章信息/Info

Title:
The preparation and property research of ultra smooth antimicrobial silicone rubber catheters
文章编号:
1672-6278 (2018)01-0101 -06
作者:
李育强1智倩倩1△杨茂丽1孔晓颖2
1.青岛明药堂医疗股份有限公司,青岛 266111;2.青岛农业大学,青岛 266109
Author(s):
LI Yuqiang1 ZHI Qianqian1 YANG Maoli1 KONG Xiaoying2
1.Qingdao Miuton Medical Share CO., LTD., Qingdao 266111,China;2.Qingdao Agricultural University, Qingdao 266109
关键词:
光催化接枝硅胶导管亲水涂层超滑抗菌
Keywords:
Photocatalytic grafting Silicone rubber catheter Hydrophilic coating Ultra smooth Antibacterial
分类号:
R318
DOI:
10.19529/j.cnki.1672-6278.2018.01.21
文献标识码:
A
摘要:
本研究采用光催化接枝的方法,在硅胶导尿管表面接枝亲水性高聚物和抗菌成分醋酸氯己定(A)、牡丹酚(B),成功制备出两种具有不同超滑抗菌涂层的导尿管,并对其结构、形貌、亲水性、润滑性、抑菌性、稳定性等进行研究。结果表明:红外光谱分析证明亲水高聚物及抗菌成分均成功接枝到导尿管表面;相比于A超滑抗菌导尿管,B超滑抗菌导尿管的涂层更加致密、均匀,亲水涂层与抗菌涂层无明显界限,融为一体,且具有更优异的润滑性能和抑菌性能,其动摩擦力低至0.012 N,体外持续抗菌时间可达40 d以上,可满足临床使用需求,具有重要的临床价值和广阔的市场前景。
Abstract:
In this article, photocatalytic grafting was adopted to prepare hydrophilic polymer on the surface of silicone rubber catheter, and then two kinds of antimicrobial agents, chlorhexidine acetate and a kind of plant extract were grafted on the surface of hydrophilic polymer. Two kinds of ultra smooth catheters with different antibacterial coating were successfully prepared, and the structure, morphology, hydrophilicity, lubricity, antimicrobial resistance and stability were studied respectively. Results show that the infrared spectrum analysis prove that hydrophilic polymer and antibacterial compounds are successfully grafted to the surface of the catheter; compared with A, the ultra smooth coating of catheter B is more dense and uniform, and there is no obvious boundaries between hydrophilic coating and antibacterial coating. B has more excellent lubricating properties and antibacterial properties than A. The dynamic friction of B is as low as 0.012 N, and the in vitro antibacterial duration of B can be more than 40 days, which can meet the demand of clinical use, and has important clinical value and broad market prospect.

参考文献/References

备注/Memo

备注/Memo:
(收稿日期:2017-05-06)△通信作者Email:zhiqianqian521@126.com
更新日期/Last Update: 2018-05-07