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Title:: A study of repetitive transcranial magnetic stimulation coil ?cooling method for small experimental animals

作者:: 郑志宇1; 张广浩2△; 霍小林2△; 1.北京市第三十五中学，北京 100032；2.中国科学院电工研究所生物电磁学北京市重点实验室，北京 100190

Author(s):: ZHENG Zhiyu1; ZHANG Guanghao2; HUO Xiaolin2; 1.Beijing NO.35 High School, Beijing 100032, China；2.Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190

Keywords:: Transcranial magnetic stimulation; Coil design; Cooling equipment; Measurement of magnetic field; Small experimental animals

摘要:: 针对SD大鼠实验中线圈缺少冷却系统的问题，本研究通过电磁场仿真的方法优化线圈形状参数，设计了一套线圈液体冷却装置，通过传热分析确定液体流速与线圈表面温度的关系。在实验中对组装好的线圈进行感应电场和温度测试。实验结果表明本研究所制作的线圈感应电场参数与仿真参数相匹配，能很好的作用在实验动物上；冷却系统具有良好的冷却效率，在常温液压油冷却下，线圈表面温度能稳定在45℃以下，且其电阻并未出现较大变化，表明本研究研制的带有冷却装置经颅磁刺激线圈系统，可以满足较长时间重复刺激的要求。实验结果为重复经颅磁刺激动物实验及其未来应用提供重要的科学依据。

Abstract:: The problem of lacking cooling systems in rats′ experiment limits the application of transcranial magnetic stimulation(TMS). In this paper,we designed a stimulating coil with liquid cooling system to solve this problem. The coil shape parameters were optimized by finite element simulation method and the velocity of cooling liquid, insulating oil, was chosen by heat transfer analysis. The induced electric field of the coil and the system cooling efficiency were measured in experiments. Results showed that the measured induced electric field matched well with simulation results and the temperature at the coil surface did not exceed 45 ℃. Therefore, the developed coil with an efficient cooling system could meet the requirement of long time repetitive stimulation. The developed coil system provides an important scientific basis for repetitive transcranial magnetic stimulation in animal experiments.