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Title:: Effects of different functional groups on biocompatibility of Graphene oxide

Author(s):: WANG Lili1; HUANG Qingli2; 1. Department of Clinical Medicine, Xuzhou Medical University, Xuzhou 221004，China；2. Basic Medical School of Xuzhou Medical University, Xuzhou 221004

Keywords:: Graphene oxide; Nanomaterials; Drug carrier; Surface modification; Cell compatibility

摘要:: 分别以3-氨丙基三乙氧基硅烷、氨基-β-环糊精、牛血清白蛋白作为修饰剂，通过水热法合成了3种不同修饰分子的石墨烯材料。然后通过透射电子显微镜、红外光谱、表面电势等手段对其结构和功能进行表征，并且通过 CCK-8 实验对其体外细胞相容性进行了探究。试验结果表明，不同功能基团修饰的石墨烯材料对Hela细胞和MDA-MB-231细胞具有不同的生物相容性。其中GO-APS生物相容性较差，GO-BSA生物相容性最好，该研究为后续进一步功能化修饰及其成为理想的药物载体打下基础。

Abstract:: In this paper, oxide Graphene (GO) materials were synthesized by hydrothermal method. Three different molecules (3-Aminopropyltriethoxysilane (APS), amino-β-cyclodextrin (β-CDs), and bovine serum albumin (BSA)) were used to modify its surface, respectively. The structures and properties of functionalized GO were characterized by transmission electron microscopy (TEM),Fourier transform infrared spectroscopy (FTIR), and Zeta potential analyzer (Zeta). The cell compatibility in vitro was investigated by CCK-8 assay. Cell viability studies show that Graphene materials modified with different functional groups have different biocompatibility to Hela cells and MDA-MB-231 cells. Among them, GO-APS has poor biocompatibility and GO-BSA has the best biocompatibility, which lays the foundation for further functional modification and its ideal drug carrier.