|本期目录/Table of Contents|

[1]张晓敏△,邓金.脂肪族聚酯类生物材料表面仿生磷脂化改性技术的研究*[J].生物医学工程研究,2019,02:206-210.
 ZHANG Xiaomin,DENG Jin.Study on biomimetic phospholipid modification of aliphatic polyester biomaterials[J].Journal of Biomedical Engineering Research,2019,02:206-210.
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脂肪族聚酯类生物材料表面仿生磷脂化改性技术的研究*(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2019年02期
页码:
206-210
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Study on biomimetic phospholipid modification of aliphatic polyester biomaterials
文章编号:
1672-6278 (2019)02-0206-05
作者:
张晓敏1△ 邓金2
1.河北北方学院附属第一医院 ,河北 张家口 075000;2.河北北方学院理学院,河北 张家口 075000
Author(s):
ZHANG Xiaomin1 DENG Jin2
1.The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;2.College of Science, Hebei North University,Zhangjiakou 075000
关键词:
脂肪族聚酯生物材料表面仿生磷脂化改性技术生物相容性
Keywords:
Aliphatic polyester Biomaterials Surface Biomimetic phospholipidization Modification technology Biocompatibility
分类号:
R318.08
DOI:
10.19529/j.cnki.1672-6278.2019.02.16
文献标识码:
A
摘要:
利用等离子体能量粒子使脂肪族聚酯类生物材料表面分子激发、电离、断键等特性改变,产生新的拓扑结构的可行性较低。研究对脂肪族聚酯类生物材料表面仿生磷脂化改性,运用2-氯-1,3,2-二氧磷杂环戊烷与不同原料溶液反应合成磷脂单体\[2-(甲基丙烯酰氧)乙基\]磷脂酰胆碱;将\[2-(甲基丙烯酰氧)乙基\]磷脂酰胆碱、丙烯腈和水共聚生成PANCMPC;将 \[2-(甲基丙烯酰氧)乙基\]磷脂磷脂酰胆碱替换为PANCMPC,重复共聚过程,获取PANCHEMA;将PANCHEMA和2-氯-2-氧-1,3,2-二氧磷杂环戊烷实施反应,然后与三甲胺实施开环反应,生成仿生磷脂化改性PLCANCP。实验证明,改性后的材料具有较好的亲水性、生物相容性和抗污染性。
Abstract:
It is low feasibility using plasma energy particles to excite, ionize and break bonds molecules on the surface of aliphatic polyester biomaterials to produce new topological structures. The biomimetic phosphatidylcholine modification technology of aliphatic polyester biomaterials was studied.The phosphatidylcholine monomer \[2-(methacryloxy) ethyl\]phosphatidylcholine was synthesized by reaction of 2-chloro-1,3,2-dioxaphosphoric heterocyclic pentane with different raw material solutions; the phosphatidylcholine \[2-(methacryloxy) ethyl\]phosphatidylcholine, acrylonitrile and water were copolymerized to form PANCMPC; the phosphatidylcholine \[2-(methacryloxy) ethyl\]phosphatidylcholine was replaced by PANCMPC, and PANCHEMA was obtained by repeated copolymerization. PANCHEMA was reacted with 2-chloro-2-oxygen-1,3,2-dioxophosphorus heterocyclic pentane, and then opened with trimethylamine to form biomimetic phospholipid modified PLCANCP. Experiments show that the proposed technology has good hydrophilicity, biocompatibility and pollution resistance.

参考文献/References

备注/Memo

备注/Memo:
(收稿日期:2019-01-10)河北省卫计委资助项目(2016HB116)。△通信作者Email:1062354079@qq.com
更新日期/Last Update: 2019-07-18