[1]杨滨羽,罗霞,刘佳伶,等.葡聚糖包裹超顺磁性氧化铁纳米材料用于关节软骨磁共振T2-Map成像研究[J].生物医学工程研究,2020,01:36-40.
YANG Bingyu,LUO Xia,LIU Jialing,et al.The application of dextran-coated superparamagnetic Fe3O4 nanomaterials to magnetic resonance T2-Map imaging of articular cartilage[J].Journal of Biomedical Engineering Research,2020,01:36-40.
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葡聚糖包裹超顺磁性氧化铁纳米材料用于关节软骨磁共振T2-Map成像研究(PDF)
《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
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2020年01期
- 页码:
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36-40
- 栏目:
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- 出版日期:
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2020-03-25
文章信息/Info
- Title:
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The application of dextran-coated superparamagnetic Fe3O4 nanomaterials to magnetic resonance T2-Map imaging of articular cartilage
- 文章编号:
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1672-6278 (2020)01-0036 -05
- 作者:
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杨滨羽1; 罗霞1; 刘佳伶1; 何淼1; 李偲羽1; 严浩吉1; 吴君2△
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1.川北医学院影像学院医学影像诊断专业,四川 南充 637000;2.川北医学院影像学院生物医学工程教研室,四川 南充 637000
- Author(s):
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YANG Bingyu1; LUO Xia1; LIU Jialing1; HE Miao1; LI Siyu1; YAN Haoji1; WU Jun2
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1.Medical Imaging Department, North Sichuan Medical College,Nanchong 637000,China;2.Department of Biomedical Engineering, North Sichuan Medical College,Nanchong 637000
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- 关键词:
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葡聚糖; 超顺磁性氧化铁; 关节软骨; 磁共振; T2-Map; 普鲁士蓝染色
- Keywords:
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Dextran; Superparamagnetic iron oxide; Articular cartilage; Magnetic resonance; T2-Map; Prussian blue staining
- 分类号:
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R318
- DOI:
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10.19529/j.cnki.1672-6278.2020.01.08
- 文献标识码:
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A
- 摘要:
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本研究制备了粒径(18±2) nm的葡聚糖包裹的超顺磁性氧化铁纳米颗粒,作为磁共振T2造影剂,对兔关节软骨进行增强磁共振T2-Map成像,并分析注射前后24 hT2弛豫时间的变化,发现T2弛豫时间均下降。行组织病理学普鲁士兰染色,发现软骨基质及细胞内均有氧化铁纳米颗粒的存在,说明葡聚糖包裹超顺磁性氧化铁纳米材料可应用于关节软骨磁共振增强成像。
- Abstract:
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We prepared dextran-coated superparamagnetic Fe3O4 nanoparticles with particle size of 18 nm±2 nm as a magnetic resonance T2 contrast agent,to perform the enhanced magnetic resonance T2-Map imaging of rabbit articular cartilage, and analyzed the change in T2 relaxation time before and after injection 24 h,We found that the T2 relaxation time decreased. Histopathology Prussian blue staining revealed the presence of Fe3O4 nanoparticles in the cartilage matrix and cells. It shows that dextran-encapsulated superpararnagnetic iron oxide(SPIO) nanomaterials can be applied to magnetic resonance imaging of articular cartilage.
备注/Memo
- 备注/Memo:
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(收稿日期:2019-08-14)△通信作者Email:topmudwj@aliyun.com
更新日期/Last Update:
2020-04-14