|本期目录/Table of Contents|

[1]高卉,程云章△,刘祥坤.颅内动脉瘤径颈比对瘤体与分支血管血流动力学影响的数值模拟研究*[J].生物医学工程研究,2020,01:55-61.
　GAO Hui,CHENG Yunzhang,LIU Xiangkun.The effects of intracranial aneurysm aspect ratio on hemodynamic of tumor and branch vessel using numerical simulation method[J].Journal of Biomedical Engineering Research,2020,01:55-61.
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颅内动脉瘤径颈比对瘤体与分支血管血流动力学影响的数值模拟研究*(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2020年01期
页码:
55-61
栏目:
出版日期:
2020-03-25

文章信息/Info

Title:
The effects of intracranial aneurysm aspect ratio on hemodynamic of tumor and branch vessel using numerical simulation method
文章编号:
1672-6278 (2020)01-0055 -07
作者:
高卉1; 程云章1△; 刘祥坤1; 2
1.上海理工大学 上海介入医疗器械工程技术研究中心，上海 200093；2.上海微创医疗器械（集团）有限公司 ， 上海 201203
Author(s):
GAO Hui1 ; CHENG Yunzhang1 ; LIU Xiangkun1; 2
1.Shanghai Engineering Research Center of Interventional Medical Devices,University of Shanghai for Science and Technology,Shanghai 200093, China;2.Shanghai MicroPort Medical (Group) Co., Ltd.,Shanghai 201203
关键词:
径颈比; 颅内动脉瘤; 血流动力学; 计算流体力学; 数值模拟
Keywords:
Aspect ratio;  Intracranial aneurysm;  Hemodynamics;  Computational fluid dynamics;  Numerical simulation
分类号:
R318.5
DOI:
10.19529/j.cnki.1672-6278.2020.01.11
文献标识码:
A
摘要:
动脉瘤的血流动力学是影响其生长与破裂的重要因素，尤其是形态学参数径颈比(aspect ratio,AR,瘤体长径/瘤颈宽度)对其血流动力学影响较大。本研究使用基于计算流体力学(computational fluid dynamics, CFD)技术的ANSYS 16.0软件包，数值仿真分析了不同径颈比对颅内动脉瘤瘤体与分支血管血流动力学的影响，为临床上制定合理的形态学与血流动力学指标来筛选高危的动脉瘤患者，并进行积极的干预治疗提供一定的理论依据。通过使用空间直角坐标系建立径颈比为3.33、2.5、2、1.67、1.43、1.25的理想颅内动脉瘤几何模型，分析和比较了包括血液流场与涡量分布、流速与流量、壁面压力、壁面切应力(wall shear stress, WSS)、瘤颈近远侧端与分支血管剪切应变率(shear strain rate, SSR)在内的血流动力学参数。数值模拟结果给出了动脉瘤与分支血管内的流线图、涡核图、压力分布云图、WSS分布云图以及随X轴变化的流速与压力峰值分布曲线。分析得出，径颈比决定瘤内血流模式，径颈比减小，瘤顶的流速与SSR增大，瘤壁上的压力与WSS增大，分支血管壁上的压力增大，且WSS/SSR瘤颈远侧端> WSS/SSR瘤颈近侧端> WSS/SSR分支血管中心，涡核区域由瘤体远侧壁增大至覆盖整个动脉瘤，但对分支血管内血流的阻碍作用减小。
Abstract:
Intracranial aneurysm hemodynamics is an important factor affecting the growth and rupture of tumors, especially morphological parameter aspect ratio (AR, tumor length/neck width) has a great influence on hemodynamic changes. Our research used numerical simulation with ANSYS 16.0 software based on computational fluid dynamics(CFD) technology to analyze the effects of different ARs on hemodynamic diversity of cerebral aneurysms and their branches, offered some theoretical basis to filter the high-risk aneurysm patients,and do aggressive therapies by establishing reasonable morphological and hemodynamic parameters clinically.We built six ideal geometric arterial aneurysmal models(AR=3.33，2.5，2，1.67，1.43，1.25) after setting up the space coordinate system; and took several vital hemodynamic indexes to analyze and compare the parameters including blood flow field，vorticity distribution，mass flow and velocity，wall pressure，wall shear stress(WSS)，shear strain rate(SSR) of proximal and distal neoplasia necks and branch vessel. Streamlines,vortex core regions,wall pressure and WSS contours within aneurysms and branches as well as maximal velocity and pressure distribution curves along the X-axis were given through the simulation procedure. Our study show that AR determines the flow pattern within the tumor. As AR decreases, the velocity and SSR of the aneurysm roof increases, the pressure and WSS on aneurysm wall increases, and the stress on branch vessel wall also increases, WSS/SSRdistal neoplasia neck>WSS/SSRproximal neoplasia neck>WSS/SSRbranch vessel center, vortex core regions enlarges from the distal wall of the tumor to the entire body, but the obstruction to the branch vessel flow is reduced.

参考文献/References

备注/Memo

备注/Memo:
（收稿日期：2019-08-05）上海工程技术研究中心资助项目（18DZ2250900）。△通信作者Email：cyz2008@usst.edu.cn
更新日期/Last Update: 2020-04-15