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Title:: Application of chitosan-graphene oxide composite hydrogel in bone defect

作者:: 王雅倩1; 2; 3; 5; 洪莹莹1; 2; 3; 5; 周小莉4; 5; 宋健4; 5; 詹玉林1; 2; 3; 5△; 1.上海海洋大学水产科学国家级实验教学示范中心，上海 201306；2.上海海洋大学科学技术部海洋生物科学国际联合研究中心，上海 201306；3.上海海洋大学农业部淡水水产种质资源重点实验室，上海 201306；4.上海中医药大学健康医学院，上海201203；5.上海健康医学院附属第六人民医院东院骨科，上海 201306

Author(s):: WANG Yaqian1; 2; 3; 5; HONG Yingying1; 2; 3; 5; ZHOU Xiaoli4; 5; SONG Jian4; 5; ZHAN Yulin1; 2; 3; 5; 1.Shanghai Ocean University，National Demonstration Center for Experimental Fisheries Science Education,Shanghai 201306,China;2.Shanghai Ocean University，International Research Center for Marine Biosciences, Ministry of Science and Technology , Shanghai 201306;3.Shanghai Ocean University，Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai 201306;4. School of Health Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203;5. Department of Orthopedics East Hospital of Shanghai Sixth People′s Hospital Affiliated to Shanghai University of Medical & Health Sciences,Shanghai 201306

摘要:: 随着生物医学技术的发展，制备可降解且低毒性的水凝胶材料逐渐成为治愈骨缺损的研究热点。壳聚糖与氧化石墨烯复合材料具有良好的生物相容性、生物可降解性以及有利于成骨分化等优点，制成的水凝胶在治愈骨缺损方面展现出很好的应用前景。本文主要综述了壳聚糖与氧化石墨烯及其复合水凝胶材料在骨缺损中的应用，包括壳聚糖与氧化石墨烯水凝胶和其与金属离子、无机材料组成的三相复合物在骨缺损和骨感染中的应用，还可以包载一些抗炎、抗菌的药物以及一些生长因子，例如：万古霉素、辛伐他汀、BMP-2等,为骨缺损和骨修复的治疗提供一个新的思路。

Abstract:: With the development of biomedical technology, the preparation of degradable and low toxicity hydrogel materials has gradually become a research hotspot for curing bone defects. The chitosan and graphene oxide composites have good biocompatibility, biodegradability and osteogenic differentiation, the prepared hydrogels have a good application prospect in curing bone defects. We mainly review the application of chitosan，graphene oxide and its composite hydrogel materials in bone defects， including chitosan，graphene oxide hydrogels and their three-phase composites with metal ions and inorganic materials. In the application of bone defects and bone infections, it can also contain some anti-inflammatory, antibacterial drugs and some growth factors, such as vancomycin, simvastatin, BMP-2, etc., to provide a new idea for the treatment of bone defects and bone repair .