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Title:: Design of 3D transparent tissue-mimicking phantom for radiofrequency ablation

Author(s):: ZOU Jincheng; HOU Ruizhe; WANG Hongying; ZHAO Shiqing; ZHANG Aili; （School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030，China）

Keywords:: 3D transparent; Tissue-mimicking phantom; Radiofrequency; Ablation; Muscle tissue; Electrical characteristics

摘要:: 为更好地研究射频精准消融的治疗方法，本研究设计了一种能够模拟生物组织电学特性的三维可视化聚丙烯酰胺胶体。本研究对比测试了胶体与肌肉组织在100 kHz～2 MHz频率的电学特性，并利用自主研发的射频消融系统，探究了460 kHz频率下的胶体加热特性。研究发现，本研究制备的透明仿生胶体可在局部温度达到阈值后迅速变白，透明度发生剧烈变化，且变白区域的形状及大小的动态变化可被实时观测。本研究胶体较适用于500 kHz以下的射频消融，胶体与瘦肉在消融过程中具有相同的阻抗变化曲线，并在3 min内消融范围基本相同。本胶体有利射频消融技术的临床研究。

Abstract:: In order to study the better precision treatment methods of radiofrequency ablation (RFA),We developed a three-dimensional transparent polyacrylamide phantom,which can simulate the electrical properties of biological tissue. At first, the electrical properties of the phantom and muscle were measured and compared in the range of 100 kHz~2 MHz. Then, the heating characteristics of the phantom at 460 kHz were studied by using the self-developed RFA system. The results showed that the transparent tissue-mimicking phantom became white rapidly and the transparency changed dramatically, once the regional temperature reached the threshold. And the dynamic changes of the shape and size of the whiten area could be observed in real time. This phantom was more suitable for the RFA with the frequency below 500 kHz. It was also found that the phantom had the same impedance curve as the muscle during RFA, and the range of ablation at 3 min was almost the same.This phantom is benefical to the clinical research of radiofrequency ablation.