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Title:: Numerical simulation analysis of the effect of inhalation-pressure interval on the asthma drug particle deposition

Author(s):: YAN Sixin; FENG Sen; CUI Biao; ZHANG Zhiguo; （College of Mechanical and Electronic Engineering, Hohai University, Changzhou 213002, China）

Keywords:: Asthma; Metered-dose inhaler; Computational fluid dynamics; Inspiration-press interval; Deposition rate

摘要:: 为分析吸气-按压间隔时间Δt对药物颗粒在体沉积的影响，本研究采用数值仿真方法分析了哮喘患者在使用定量吸入器时药物颗粒在体沉积的分布情况。首先，通过CT数据重建人体呼吸道模型；然后，建立与呼吸道模型相结合的哮喘定量吸入器模型；最后，采用计算流体动力学方法对哮喘药物颗粒的在体传输进行数值仿真。结果表明，随Δt的缩短，药物颗粒在口咽喉的沉积率逐渐下降，而下气道的颗粒沉积率逐渐升高。当Δt=0 s时，颗粒在口咽喉部位的沉积率下降到最低值49.87%，而进入下气道的颗粒达到最高值，为35.04%。本研究可为今后智能辅助给药技术提供重要的理论指导，从而提高给药效率。

Abstract:: In order to analyze the effect of inspiration-press interval on the deposition of drug particles in vivo, the numerical simulation was used to analyze the distribution of drug particles in vivo deposition in asthma patients when using metered-dose inhalers. Firstly, the 3D numerical model of human respiratory tract was reconstructed from CT data obtained in clinic. Then, the geometric model of asthma metered-dose inhaler was established and combined with the previous respiratory model. Finally, the computational fluid dynamics method was used to simulate the in vivo transport of asthma drug particles. The results showed that with the Δt shortened, the deposition rate of drug particles in the oropharynx gradually decreased, while the deposition rate of particles in the lower airway gradually increased. When Δt=0 s, the deposition fraction of particles in the oropharynx decreased to the lowest value of 49.87%, and the corresponding particles entering the lower airway reached the highest value of 35.04%. It can provide important theoretical guidance for intelligent assisted drug delivery technology in the future, so as to improve the efficiency of drug delivery.