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Title:: Assessment of brain function in mild cognitive impairment and Alzheimer′s disease based on functional near-infrared spectroscopy

作者:: 王泽华1; 田一竹1; 武迪1; 汪待发1; 李德玉1△; 夏美云2; （1.北京航空航天大学生物与医学工程学院，北京 100191；2.北京航空航天大学机械工程及自动化学院，北京 100191）

Author(s):: WANG Zehua1; TIAN Yizhu1; WU Di1; WANG Daifa1; LI Deyu1; XIA Meiyun2; （1.School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China；2.School of Mechanical Engineering and Automation, Beihang University, Beijing 100191）

Keywords:: Alzheimer′s disease; Mild cognitive impairment; Functional near-infrared spectroscopy; Functional connectivity; Brain activation

摘要:: 为探究阿尔茨海默病(Alzheimer′s disease，AD)、轻度认知障碍(mild cognitive impairment，MCI)患者与健康老年群体(healthy control population, HC)的脑活动差异。本研究对24名AD患者、27名MCI患者与20名健康老年受试者进行静息态和任务态数据采集，计算基于氧合血红蛋白(oxygenated hemoglobin, HbO₂)和脱氧血红蛋白(deoxygenated hemoglobin, HbR)的脑激活和脑连接，进行单因素方差分析，建立脑功能指标与行为的关联关系, 并获得了5个具有显著组间差异且与行为显著相关的关键指标。结果显示，三组间，基于HbO₂信号的脑激活差异性更强，而基于HbR信号的脑功能连接差异性更强；受试者HbR功能连接与任务正确率显著正相关，与反应时间显著负相关。脑功能活动的差异可能是行为差异的神经机制，本研究将有助于MCI和AD的早期评估。

Abstract:: In order to investigate the difference in brain activity between Alzheimer′s disease (AD)，mild cognitive impairment (MCI) patients and healthy control population (HC), resting state and task state data were collected from 24 AD patients, 27 MCI patients, and 20 normal elderly subjects. The brain activation and brain connectivity were calculated based on oxygenated hemoglobin (HbO₂) and deoxygenated hemoglobin (HbR). One-way analysis of variance was performed, the correlation between brain function and behavior was established, and five key indicators with significant inter-group differences and significant correlation with behavior were obtained. The results showed that there were significant differences in brain activation based on HbO₂ signal and functional connectivity based on HbR signal among the three groups. The differences in brain activation based on HbO₂ signals were stronger, while the differences in functional connectivity based on HbR signals were stronger. The functional connection based on HbR was positively correlated with task accuracy and negatively correlated with reaction time. Differences in brain functional activity may be the neural mechanism of behavioral differences and this study will contribute to the early assessment of MCI and AD.