[1]李红梅△,史文红,罗西友,等.透明质酸和EDC的轻度交联研究[J].生物医学工程研究,2011,04:232-233.
LI Hongmei,SHI Wenhong,LUO Xiyou,et al.Research on Little Cross-linking of Hyaluronic with Carbodiimides[J].Journal of Biomedical Engineering Research,2011,04:232-233.
点击复制
透明质酸和EDC的轻度交联研究(PDF)
LI Hongmei,SHI Wenhong,LUO Xiyou,et al.Research on Little Cross-linking of Hyaluronic with Carbodiimides[J].Journal of Biomedical Engineering Research,2011,04:232-233.
《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
- 2011年04期
- 页码:
- 232-233
- 栏目:
- 论著
- 出版日期:
- 2011-12-30
文章信息/Info
- Title:
- Research on Little Cross-linking of Hyaluronic with Carbodiimides
- Author(s):
- LI Hongmei; SHI Wenhong; LUO Xiyou ; ZHANG Suwen
- Shandong Medical Instruments Institute, Jinan250013，China
- 关键词:
- 透明质酸（HA）; 碳化二亚胺（EDC）; 化学修饰; 衍生物; 轻度交联
- Keywords:
- Hyaluronic acid（HA）; Carbodiimides（EDC）; Chemical modification derivations; Mild cross-linking
- 分类号:
- R318
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 我们用水溶性的碳化二亚胺（EDC）作为交联剂对透明质酸（HA）进行轻度交联，得到溶 于水的产物。通过控制交联剂的使用量和反应时间，不同分子量的HA，其轻度交联的条件也不一样。对HA和碳化二亚胺的轻度交联作了初 步的研究。
- Abstract:
- Hyaluronic acid(HA) was little cross-linked with water-soluble Carbodiimides，got soluble product which was maked by regulate the usage amount of cross-linking agent and response time,the molecular weight of HA was different,the cross-linking condition was different.
参考文献/References
［1］杨好，熊文说，应国清，等.交联透明质酸衍生物的制备与应用进展［J］.化工进展，2006,25(12):1410-1414.
［2］Balazs Endre A,Adolf L,Adelya L，etc. Hylan preparation and method of recovery thereof from animal tissues.［P］US5099013.
［3］林枞，徐政，顾其胜，等.碳化二亚胺对透明质酸进行化学修饰的研究［J］.上海生物医学工程，2004，25（1）：17-21.
［4］Jing-wen Kuo，Swann D A，Prestwich G D，Chemical modification of hyaluronic acid by carbodiimides［J］Bioconjugate Chem.,1991,2:232-241.
备注/Memo
- 备注/Memo:
- △通信作者Email:yijianmei2003@163.com
常用功能
统计/Statistics
- 摘要浏览/Viewed2693
- 全文下载/Downloads1810
- 评论/Comments
更新日期/Last Update:
2011-12-30