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Title:: The Research of Individualized Modeling based on Diastolic Time for Blood Pressure

作者:: 洪溪1; 2; 李烨1; 何青云1; 林剑华1; 2; 刘利明1; 苗芬1△; 1.中国科学院深圳先进技术研究院生物医学信息技术研究中心，深圳 518055；2.华中科技大学光学与电子信息学院，武汉 430074

Author(s):: HONG Xi1; 2; LI Ye1; HE Qingyun1; LIN Jianhua1; 2; LIU Liming1; MIAO Fen1; 1.Research Center for Biomedical Information Technology, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen 518055，China；2. School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074，China

Keywords:: Blood pressure; Diastolic Time; Photoplethysmography; Cuff-less; Pulse transit time

摘要:: 本研究提出了一种基于脉搏波舒张期时间（diastolic time，DT）的无袖带式血压估计方法，能够有效提升可穿戴式设备的血压测量精度。该方案首先从脉搏波（photoplethysmography，PPG）中提取DT，再利用线性回归方法建立个体化血压估计模型。本研究对采集的30个样本的实验数据，进行血压建模并加以验证，实验结果显示收缩压的平均误差为1.859 mmHg，标准差为5.640 mmHg；舒张压的平均误差为1.049 mmHg，标准差为6.107 mmHg，证明了该方案的可行性。通过将该方案的估计结果与基于脉搏波传导时间（pulse transit time，PTT）的血压模型的估算结果进行对比研究,结果表明交感神经活动较强时，基于DT的血压模型能够有效提升血压估计精度。

Abstract:: To propose a cuff-less blood pressure measurement method based on diastolic time of photoplethysmography，it could effectively improve the estimation accuracy for wearable devices. By using linear regression between diastolic time and blood pressure, individualized blood pressure estimation model was established. Blood pressure models were built on the data from 30 volunteers and the performance of the models were tested. The experiment result showed that the mean difference and standard deviation between the estimated value and reference value were (1.859±5.640) mmHg for SBP and(1.049±6.107) mmHg for DBP，it demonstrated the feasibility of the method. Finally, the result were compared to the result from the model based on pulse transit time.It shows that the method proposed can effectively improve BP estimation accuracy while sympathetic nerve activity is strong.