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Title:: Preparation of PEG/PLGA Composite Nanofibers and its Parameters Optimization

作者:: 赵月1; 2; 陈灶妹1; 2; 何婷3; 陈柯君1; 2; 江丽2; 张俊辉3; 万华印3; 李茹冰2△; 1.广东药科大学，广东广州 510006；2.广州军区广州总医院，广东广州 510010；3.广州市电纺生物科技有限公司，广东广州 510604

Author(s):: ZHAO Yue1; 2; CHEN Zaomei1; 2; HE Ting3; CHEN Kejun1; 2; JIANG Li2 ; ZHANG Junhui3; WAN Huayin3; LI Rubing2; 1.Guangdong Pharmaceutical University, Guangzhou 51006,Guangdong,China；2.Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 510010,Guangdong ；3.Guangzhou Electrospinning Biological Technology Co., Ltd., Guangzhou 510604,Guangdong

Keywords:: Electrospinning ; Mechanical property; Response surface methodology; Box-Behnken design; Hydrophilic

摘要:: 通过静电纺丝法制备的聚乳酸-羟基乙酸共聚物（PLGA）纳米纤维膜是一种具有广阔应用前景的医用可生物降解高分子材料。为探究不同因素对纺丝过程及膜力学性能的影响，本研究采用响应面法中Box-Behnken设计，选取了PEG含量、纺丝速度和电压3个因素作为影响因子，以拉伸强度作为考察对象，通过回归分析建立了二次多元模型。结果表明，PEG含量对力学性能的影响最为显著，其次为电压的二次项；模型预测的拉伸强度值与真实值能较好的拟合，说明该模型能有效地预测PEG/PLGA复合纤维膜的力学性能。

Abstract:: The poly (lactic co glycolic acid) (PLGA) nanofiber membrane by electrospinning is a kind of biodegradable polymer material with wide application prospect. In order to investigate the influence of different factors on the spinning process and the mechanical properties of the film, Box-Behnken experimental design was employed with three main influential parameters,i.e. PEG concentration, flow rate and electric field intensity, as the independent variables and the tensile strength of the fibers as the investigative object. The results show that PEG concentration has the most significant influence on the tensile strength, and follow by the two voltage. The observed responses are in close agreement with the predicted values of the model , which shows that the mechanical properties of the model can effectively predict the PEG/PLGA composite fiber membranes.