|本期目录/Table of Contents|

[1]赵金哲,王娟,晋晓飞,等.基于反射光谱特征的肝组织热损伤动态分析*[J].生物医学工程研究,2019,01:22-26.
 ZHAO Jinzhe,WANG Juan,JIN Xiaofei,et al.Dynamic liver thermal damage analysis based on reflectance spectrum characteristics[J].Journal of Biomedical Engineering Research,2019,01:22-26.
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基于反射光谱特征的肝组织热损伤动态分析*(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2019年01期
页码:
22-26
栏目:
出版日期:
2019-03-25

文章信息/Info

Title:
Dynamic liver thermal damage analysis based on reflectance spectrum characteristics
文章编号:
1672-6278 (2019)01-0022-05
作者:
赵金哲1王娟1晋晓飞1钱志余1△李韪韬1刘珈2
1.南京航空航天大学 自动化学院 生物医学工程系,南京 211106;2.湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院,长沙 410013
Author(s):
ZHAO Jinzhe1 WANG Juan1 JIN Xiaofei1 QIAN Zhiyu1 LI Weitao1 LIU Jia2
1.Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106,China;2.Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013,China
关键词:
近红外反射光谱热消融肝脏血红蛋白
Keywords:
Near infrared Reflectance spectrum Thermal ablation Liver Hemoglobin
分类号:
R318
DOI:
10.19529/j.cnki.1672-6278.2019.01.05
文献标识码:
A
摘要:
本研究针对目前肝组织热损伤近红外光谱分析方法无法准确区分血红蛋白等主要吸光物质的问题,利用组织反射光谱在不同加热条件下的变化速率差异,分析了反射光谱变化与组织不同物质热损伤的关联。实验结果表明,利用不同波段的光谱变化速率差异可以监测肝组织损伤进程,并准确判断含氧血红蛋白和脱氧血红蛋白的热变性过程。这一方法有助于将近红外光谱技术应用于组织热损伤过程不同物质的热变性分析,进一步提高其在热消融过程实时疗效评估中的应用价值。
Abstract:
Existing near infrared spectroscopy (NIRS) methods for liver thermal damage analysis are not capable of distinguishing major chromophores of liver tissue. We studied the differences in the changing rates of tissue reflectance spectrum under various heating conditions and revealed their correlation with tissue thermal damage. The results showed that variations of reflectance spectrum changing rates could be used for the monitoring of tissue thermal damage progress, and denaturation of oxyhemoglobin and deoxyhemoglobin could also be distinguished. This method is beneficial for NIRS technique to be used in the analysis of heat denaturation of different tissue components, and enhances its significance in real-time efficacy assessment of thermal ablation therapy.

参考文献/References

备注/Memo

备注/Memo:
(收稿日期:2018-10-08)国家自然科学基金资助项目(81827803,81727804);南京航空航天大学博士学位论文创新与创优基金资助项目(BCXJ14-07)。△通信作者Email: zhiyu@nuaa.edu.cn
更新日期/Last Update: 2019-05-24