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Title:: Study on electromagnetic field and temperature field distribution in animal model during magnetic induction hyperthermia

Author(s):: LIN Yanping; LU Mai; LIU Xi; QU Yingjiao; Key Lab of Optoelectronic Technology and Intelligent Control，Ministry of Education，Lanzhou Jiaotong University，Lanzhou 730070，China

Keywords:: Magnetic induction hyperthermia; Tumor; Coil; Electromagnetic field; Temperature field

摘要:: 磁感应热疗技术的关键之一就是对肿瘤病变区的温度场分布作相对精确的控制。本研究首先利用AutoCAD三维设计软件构建出接近生物体的动物模型，设计出适用于小动物的磁感应热疗线圈装置，采用Pennes生物传热方程，研究了混合注射和血液灌注效应下温度场分布。结果表明，利用基于有限元的多物理场仿真软件COMSOL，可获得生物体与线圈装置的电磁场分布，可在肿瘤热疗区产生相对理想的温度场分布，其中正常组织体积损伤范围较小，约为0.8%，对于提高肿瘤磁感应热疗的临床安全性及磁感应热疗装置的制造有着指导意义。

Abstract:: One of the key issues in magnetic induction hyperthermia is the relatively precise control of the temperature field distribution in the tumor lesion. In this paper, AutoCAD 3D design software was used to construct an animal model. A amagnetic induction hyperthermia coil device suitable for small animals was designed. The Pennes bioheat transfer equation was used to study the temperature field distribution under mixed injection and blood perfusion effects. The results show that the electromagnetic field distribution of the living body and the coil device can be obtained by using the multi-physics simulation software COMSOL, which can generate a relatively ideal temperature field distribution in the tumor hyperthermia area, with tissue volume damage range is 0.8%. It has guiding significance for improving the clinical safety of magnetic induction hyperthermia and the manufacture of magnetic induction hyperthermia devices.