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Title:: Research progress on the osteoporosis animal model construction and experimental methods

作者:: 周静媛1; 刘肖珩2; 沈阳2; 曾烨2; 陈宇1△; 蒋文涛1; 1.四川大学生物力学工程省重点实验室，成都 610065；2.四川大学华西基础医学与法医学院，成都 610041

Author(s):: ZHOU Jingyuan1; LIU Xiaoheng2; SHEN Yang2; ZENG Ye2; CHEN Yu1; JIANG Wentao1; 1.Department of Applied Mechanics, Sichuan University,Chengdu 610065，China；2.West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University,Chengdu 610041

Keywords:: Osteoporosis; Animal model; Anilmal experiments; Primary; Secondary

摘要:: 骨质疏松症是一种全身性骨代谢病，由多种因素引起，其特点是骨量、骨密度和骨组织的显微结构恶化，骨脆性增强和易发生骨折。骨质疏松症已严重威胁人类健康，最终将导致患者日常活动减少，生活质量降低，死亡率增加。针对不同的研究对象，选择一个正确、理想的动物骨质疏松的模型和实验方法以尽可能再现人类骨质疏松的状态,是开展动物实验的关键。我们综述了当前原发性和继发性骨质疏松等动物模型的构建，以及利用这些模型进行给药实验的研究方法，并对研发治疗骨质疏松的新型药物的选择提供了一些参考建议，以期对后续关于药物的作用机制、研发新药、药物的改良等研究提供思路。

Abstract:: Osteoporosis is a systemic disease of bone metabolism, which is caused by a variety of factors. Its characterisistics are deterioration of bone mass, bone density and microstructure of bone tissue, enhancement of bone fragility and fracture prone. Osteoporosis has become a serious threat to human health and ultimately leads to reduced daily activities, quality of life and increased mortality. For different research objects, it is the key to select a correct，ideal model and experimental method of animal osteoporosis to reproduce the human osteoporosis status as much as possible. We review the current construction of animal models of primary and secondary osteoporosis, and the research methods by using these models for drug administration experiments to provide some suggestions for the development of new drugs for the treatment of osteoporosis,so as to provide some reference for the follow-up research on the mechanism of action of drugs, development of new drugs, and drug improvements.