[1]崔奎琰,汪丽燕,杨光,等.静电纺丝纤维支架抑制瘢痕形成的研究进展*[J].生物医学工程研究,2022,03:340-346.
CUI Kuiyan,WANG Liyan,YANG Guang,et al.Research progress on electrospun fibrous scaffold for scarring prevention[J].Journal of Biomedical Engineering Research,2022,03:340-346.
点击复制
静电纺丝纤维支架抑制瘢痕形成的研究进展*()
《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
-
2022年03期
- 页码:
-
340-346
- 栏目:
-
- 出版日期:
-
2022-09-25
文章信息/Info
- Title:
-
Research progress on electrospun fibrous scaffold for scarring prevention
- 文章编号:
-
1672-6278 (2022)03-0340-07
- 作者:
-
崔奎琰1; 汪丽燕1; 杨光1; 钟文2; 彭新生1; 周郁斌1△; 陈慧芝1△
-
1.广东医科大学 广东天然药物研究与开发重点实验室,药学院 东莞 523808;2.陆军第75集团军医院 皮肤病科,大理 671000
- Author(s):
-
CUI Kuiyan1; WANG Liyan1; YANG Guang1; ZHONG Wen2; PENG Xinsheng1; ZHOU Yubin1; CHEN Huizhi1
-
1. Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan 523808,China;2. Department of Dermatological, the 75th Army Hospital of PLA, Dali 671000,China
-
- 关键词:
-
静电纺丝; 伤口敷料; 纳米纤维; 瘢痕; 载药系统; 生物材料
- Keywords:
-
Electrospinning; Wound dressing; Nanofibers; Scarring; Durg-loaded system; Biomaterials
- 分类号:
-
R318
- DOI:
-
10.19529/j.cnki.1672-6278.2022.03.17
- 文献标识码:
-
A
- 摘要:
-
静电纺丝纤维支架高度模拟天然细胞外基质的纤维结构,具有比表面积大、孔隙率可控、生物性能良好等特点,有益于加速创面愈合,又可减少瘢痕形成,常用于组织修复与再生,是可降解伤口敷料领域的重要发展方向。本文对静电纺丝纤维敷料应用在伤口愈合及抑制瘢痕形成的研究现状进行综述,重点介绍了纤维支架材料和装载活性药物的研究进展,最后探究了载药/细胞纤维支架的应用潜力并对其未来发展方向进行展望。
- Abstract:
-
Electrospun fibrous scaffold highly simulates the fiber structure of nature extracellular matrix, with large surface area, controllable porosity and superior biological property, which are beneficial to promote wound healing and prevent scar forming. It is widely applied in tissue regeneration, representing an important direction in the development and fabrication of degradable wound dressings. We review the research progress on the application of electrospun nanofiber dressings in wound healing and scarring prevention,mainly introduce the research progress of fibrous scaffold materials and bioactive drug loading. Finally, the application potential of drug/cell-loaded fibrous scaffold is discussed and its future developing direction is prospected.
备注/Memo
- 备注/Memo:
-
(收稿日期:2022-02-15)广东省基础与应用基础研究基金项目(2019A1515111036,2019A1515111112)。△通信作者Email:zybresearch@126.com; chenhuizhimail@126.com
更新日期/Last Update:
2022-11-08