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Title:: Construction of self-healable multilayer structure and antibacterial properties study of imidazole salt based poly(ionic liquids)/poly(acrylic acid)

作者:: 熊晨崴1; 2; 3; 周鑫叠1; 2; 4; 周超5; 张俊杰1; 2; 王皓1; 2; 黄勇1; 2△; （1.南京医科大学附属常州第二人民医院骨科,常州 213000； 2.南京医科大学常州医学中心，常州 213000；3.大连医科大学研究生院，大连 116000；4.共和县中医院骨科，青海省海南藏族自治州共和县 811800；5.常州大学医学与健康工程学院，常州 213164）

Author(s):: XIONG Chenwei1; 2; 3; ZHOU Xindie1; 2; 4; ZHOU Chao5; ZHANG Junjie1; 2; WANG Hao1; 2; HUANG Yong1; 2; （1.Department of Orthopedics, The Affiliated Changzhou Second People′s Hospital of Nanjing Medical University, Changzhou 213000,China; 2.Changzhou Medical Center, Nanjing Medical University, Changzhou 213000;3.Department of Graduate School, Dalian Medical University, Dalian 116000,China; 4.Department of Orthopedics, Gonghe County Hospital of Traditional Chinese Medicine, Hainan Tibetan Autonomous Prefecture, Qinghai Province 811800, China; 5.Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164）

Keywords:: Self-healing coating; Poly(ionic liquids); Surface antibacterial; Coating stability; Anti-infection; Layer by layer self-assembly

摘要:: 为提高生物医学设备表面涂层的抑菌稳定性，本研究使用层层自组装技术将呋喃结构的咪唑盐聚离子液体作为聚阳离子电解质层和抗菌剂，与作为聚阴离子电解质层的聚丙烯酸接枝糠胺沉积在不锈钢表面，并通过Diels-Alder环化反应，使用双马来酰亚胺聚乙二醇交联剂将聚合物层交联起来，以提高涂层的稳定性。该多层涂层性能稳定、具有自愈性，还对金黄色葡萄球菌和大肠杆菌具有持久的抗菌活性。此外，涂层成骨细胞（MC3T3-E1）具有较低的细胞毒性。该方法可对生物医疗器械表面抗感染防护提供有效策略。

Abstract:: In order to improve the bacteriostatic stability of the surface coating of biomedical equipment, the layer-by-layer (LbL) self-assembly technique was used to deposit antibacterial furan imidazolium based poly (ionic liquids) (PILF) as cationic polyelectrolyte and antibacterial agent and poly (acrylic acid) grafting 2-furfurylamine (PAAF) as anionic polyelectrolyte on the surface of stainless steel. The polymer layers were cross-linked by bismaleimide poly(ethylene glycol) linker (MPEG) via Diels-Alder cycloaddition to enhance the stability of the coatings. The multilayer coatings not only exhibited self-healable and stable properties, but also demonstrated sustainable antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Furthermore, these coatings showed no toxicity effect towards seeded osteoblastic cells (MC3T3-E1). This method can provide effective strategy for the anti-infective protection of biomedical devices.